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KMID : 0369820170470040297
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Jorunal of Korean Pharmaceutical Sciences
2017 Volume.47 No. 4 p.297 ~ p.316
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Near infrared light-controlled therapeutic molecules release of nanocarriers in cancer therapy
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Guo Xiao Meng
You Jian
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Abstract
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Spurred by the development in materials chemistry, stimuli-responsive nanocarriers that could show sharp responses to various environmental changes have found applications in many fields including controlled drug delivery in the past few years. Among all the available stimuli, light has recently attracted much attention owing to their non-invasiveness and the possibility of remote spatiotemporal control. A large amount of photoresponsive systems have been constructed to achieve on-demand drug, gene or other kinds of cytotoxic species release in responsive to illumination of a specific wavelength in near-infrared region (NIR), which shows better tissue penetration compared to visible or ultraviolet (UV) light with shorter wavelengths. Exploration of NIR light-responsive therapeutic cargoes delivery systems opens up a new and exciting possibility for applications in nanomedicine. In this review article, we mainly focus on the recent progress in nanocarriers with different kinds of strategies to achieve NIR light-based control over the delivery process, with special emphasis on their application in NIR photo-response controlled therapeutic cargoes release and subsequent therapy. The final section reviews current challenges in the use of NIR responsive nanomaterials and potential solutions.
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KEYWORD
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Controlled release, Near infrared light, Cancer, Nanocarriers
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